I loved this movie. One of the best of the year for me ... Joseph Gordon-Levitt was absolutely amazing as a young man newly diagnosed with cancer. Anna Kendrick gives a sweetly awkward performance as the world's worst therapist. And Seth Rogan (who is basically playing himself, since the script was written by his friend Will Reiser who had cancer) gives a nice performance as someone who is trying the best he can to be supportive while not always understanding what his friend needs.
I would totally nominate JGL for Best Actor this year. I don't think he'll get a nod, but he should. I'd give this movie an 'A'.